Application Cases

Experiment Name: Dielectrophoretic Microfluidic Cell Separation Technology

Experiment Principle: Under the influence of an external electric field, cells become polarized to varying degrees and align in the direction of the applied field. When subjected to a non-uniform electric field, polarized particles experience dielectrophoretic forces, which can be used to manipulate small cells.

Testing Equipment: High-voltage amplifier, signal generator, oscilloscope, host computer, etc.

Figure: Block Diagram of the Experimental System

Experiment Process:

Figure: Photograph of the Experimental Setup

The host computer outputs a voltage signal of 0-5V, which is input into the power amplifier. The power amplifier amplifies this signal to 0-1000V, which excites the probe to generate a voltage. Meanwhile, cells to be sorted are continuously injected into the container, and the sorting results are inspected using a laser sensor.

Experimental Results:

Cell identification and separation using suspended cells. Consistent dielectric differences were observed between transformed normal cells and comparable normal cells, as well as between all types of cancer cells studied and normal cell subpopulations in peripheral blood.

Role of the Power Amplifier: To provide a high stability, low-distortion high-voltage signal of 0-1000V to drive the probe.

High-Voltage Amplifier Recommendation: ATA-7000 Series

Figure: Specification Parameters of the ATA-7000 Series High-Voltage Amplifiers

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