Application Cases

Experiment Name: The Application of Power Amplifiers in Acoustic Cavitation Microfluidic Devices

Experiment Content:An acoustic cavitation microfluidic device was constructed. Research was conducted on the theoretical model and mechanism of the acoustic cavitation microfluidic device, its design and fabrication, and the synthesis of liposomal drugs using the device. A new method for precisely controlling the size distribution of liposomal drugs based on acoustic cavitation microfluidic devices was developed.

Research Direction: Acoustic Cavitation Microfluidic Mixing

Testing Equipment:ATA-2031 power amplifier, signal generator, ultrasonic transducer, etc.

Figure: Experimental Process

Experimental Process:

The signal generator and power amplifier were connected, with the positive and negative terminals of the power amplifier connected to the corresponding terminals of the acoustic cavitation microfluidic device. Using a micro-injection pump, buffer solution and lipid ethanol were injected into the buffer inlet and lipid ethanol solution inlet, respectively, at specific flow rates. Meanwhile, the signal generator and power amplifier were turned on, with different input voltages set. As the lipid organic solution mixed with the buffer in the fluid focusing mixing unit, the organic solvent rapidly dissolved in the aqueous phase, significantly reducing its concentration and enabling the rapid formation of liposomes from lipid molecules in the buffer. Additionally, the acoustic cavitation microfluidic device can generate acoustic cavitation effects within the channel, further enhancing mixing efficiency and influencing the initial state of lipid molecule self-assembly. The experiment tested three conditions with flow rate ratios (FRR) of 3, 4, and 5, and input voltage peak-to-peak values of 100 V, 200 V, and 300 V, respectively.

Experimental Results:

A systematic optimization study was conducted on the process parameters of the acoustic cavitation microfluidic device. It was observed that the formation of liposomes was closely related to the intensity of acoustic cavitation, with an appropriate increase in voltage significantly enhancing the intensity of the acoustic cavitation effect within the microfluidic channel, thereby improving the efficiency of microfluidic mixing. Moreover, the device was experimentally verified to be effective for synthesizing liposomes with different excipients. Regarding the frequency of the ultrasonic transducer, the study also found that appropriate frequency settings are crucial for optimizing cavitation efficiency. This part of the research not only provides a scientific basis for the application of acoustic cavitation microfluidic devices in liposomal drug synthesis but also lays the foundation for subsequent drug preparation and application optimization.

Power Amplifier Recommendation: ATA-2031 High-Voltage Amplifier

Figure: Performance Parameters of the ATA-2031 High-Voltage Amplifier

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