Application Cases

Magnetic Nanoparticle Imaging (MPI) is a tracer-based imaging technique that detects the nonlinear magnetization process of magnetic nanoparticles in response to dynamic magnetic fields to obtain their three-dimensional spatial distribution. It offers advantages such as high sensitivity, high spatial resolution, fast imaging speed, and absence of harmful radiation, holding significant research value in medical imaging detection and diagnosis, particularly in the fine imaging of cardiovascular and cerebrovascular systems. Additionally, MPI has the potential to overcome the limitations of molecular imaging in terms of imaging depth, sensitivity, resolution, and radiation exposure, positioning itself as a new trend in the development of advanced medical imaging and representing the international academic frontier in modern medical imaging.

The ATG/A-3000/300 series power amplifiers produced by Aigtek can drive coils to generate excitation magnetic fields and construct test platforms. They are capable of outputting stable arbitrary waveforms, making them suitable for coil driving experiments in a wide range of application scenarios.

Experiment Name: Research on Open-Structure Magnetic Nanoparticle Vascular Fine Imaging Methods

Experimental Principle:
The experimental principle of MPI is based on the nonlinear magnetization characteristics of magnetic nanoparticles in zero magnetic fields. Magnetic nanoparticles are injected into the target as tracers. Under the influence of a magnetic field, these magnetic nanoparticles become magnetized. A gradient static magnetic field is used to create a linear zero magnetic field, which determines the position of the tracer. Under the action of a uniform alternating magnetic field, the linear zero magnetic field is translated and scanned. When the magnetic nanoparticles are at the zero magnetic field point, their magnetic susceptibility undergoes nonlinear changes. By detecting this nonlinear magnetization response, the spatial distribution of the magnetic nanoparticle tracer can be imaged.

Experimental Block Diagram:

Experimental Setup Image:

Experimental Procedure:
A programmable DC power supply is controlled via host computer software to continuously input current signals into electromagnetic coils, enabling linear zero magnetic field scanning. Simultaneously, the host computer interface controls the power signal source ATG-309 to generate a sinusoidal signal. The excitation signal is applied to the excitation coils, causing magnetic nanoparticles within the linear zero magnetic field to produce a nonlinear magnetization response due to the excitation magnetic field. A planar gradient detection coil, combined with an iterative compensation algorithm, is then used to detect the particle-induced voltage signal. Finally, the particle voltage signal is filtered and amplified before being transmitted via a data acquisition card to the host computer software for data reading, processing, and display.

Application Areas:
Biomedical, Materials Science

Application Scenarios:
Vascular fine imaging, cancer hyperthermia, targeted drug delivery, minimally invasive surgery guidance, tumor imaging and monitoring, nervous system imaging, cell tracking and imaging, material performance evaluation

Product Recommendation:
ATA-3000/300 Series Power Amplifier

Figure: ATA-3000 Series Power Amplifier Specifications