Application Cases

Experiment Name: Acoustic Field-Driven Single-Cell Motion Experiment

Research Direction: Cell Manipulation

Testing Equipment: ATA-2022B high-voltage amplifier, signal generator, piezoelectric transducer, single cell, micro/nano manipulator, camera, etc.

Experiment Process:

Figure: Schematic Diagram of the Experiment

An electrical driving signal is generated by the signal generator, amplified by the power amplifier with a preset gain, and then loaded onto the piezoelectric transducer. The transducer is coupled to the liquid environment via a supporting structure, generating a spatial acoustic field distribution. The bubble held by the manipulator's end effector oscillates radially under the characteristic frequency of the acoustic field, inducing acoustic radiation forces and forming a gradient microflow field. This composite physical field acts on the target cell via the acoustic streaming effect, achieving precise control of its displacement and rotation angle.

Experimental Results: In terms of rotational dynamics, the system examined the response characteristics of the rotational speed of small biological samples to voltage gradients under constant frequency driving. Quantitative analysis showed that the flow velocity (u) in water is proportional to the square of the bubble amplitude (A), i.e., u∝A². The amplitude is linearly related to the input voltage (V), A=k·V. Thus, the rotational speed (ω) is proportional to the square of the voltage, ω∝V². The data fitting results match the theoretical derivation. Further evaluation of angular velocity stability through angle-time sampling shows that the periodic average deviation rate and rotational phase delay meet the expected technical requirements.

Power Amplifier Recommendation: ATA-2022B High-Voltage Amplifier

Figure: Specification Parameters of the ATA-2022B High-Voltage Amplifier